DSIP sleep peptide protocol — the house pre-sleep schedule in mcg and clicks

What DSIP is and what it is studied for

DSIP is a nine-amino-acid peptide first isolated from the blood of rabbits in slow-wave sleep, and named for what it appeared to do. It is studied for sleep architecture — the proportion of deep, slow-wave sleep in a night — and for the stress axis, rather than simply for falling asleep. It is not a sedative and does not knock anyone out.

The house window is 100–300 mcg, pre-sleep, once a night, and that is the whole protocol. The doses are small enough that a 10 mg pen covers an entire cycle. What matters is the timing — 30–60 minutes before lights out, at the same time every night — and the sleep log, because the right read is the eight-week trend, never a single bad night.

Who it suits — and who should not run it

Written for the adult researcher whose sleep is long enough but not deep enough: early waking, light sleep that any noise breaks, or eight hours that still feel like five. It is also written for the researcher whose recovery from training has stalled and whose sleep tracker, if they have one, shows deep sleep as the missing piece. The house exclusions:

Not for

• Untreated sleep apnoea, or loud snoring with daytime sleepiness that has not been assessed — that is a sleep study first, not a peptide.
• Any sedative, sleep medication or opioid without the explicit agreement of the prescribing physician.
• Pregnant, breastfeeding, or planning pregnancy in the next 6 months.
• Under 18.
• Shift work with a rotating schedule — the protocol depends on a fixed bedtime.

Start gate: two weeks of a sleep log before the first dose, so there is a baseline to compare the cycle against.

The house protocol

Once nightly, subcutaneous in the abdomen a hand's width from the navel, alternating sides, 30–60 minutes before lights out, at a fixed bedtime. Seven nights a week. One pen = 300 clicks. The 10 mg pen delivers 33.3 mcg per click; the 5 mg pen delivers 16.7 mcg per click, so the same dose is twice the clicks.

Two phases: a two-week run-in at 100 mcg, the bottom of the window, then a six-week working phase at 200 mcg. 300 mcg is the soft ceiling and is reserved for the researcher whose log at week 5 shows no change — it is a coach decision, not a self-adjustment, and it is never exceeded.

Click total on the 10 mg pen: 14 nights × 3 = 42, plus 42 nights × 6 = 252, for 294 clicks → 1 pen (300 clicks), with 6 clicks to spare. On the 5 mg pen the same cycle is 588 clicks → 2 pens (600 clicks). A 3-click dose is a very small turn of the dial; the 5 mg pen gives more resolution for the researcher who finds that fiddly. Keep the pen in the fridge between uses.

DSIP is reported as well tolerated. A heavy-limbed feeling in the first few nights is the usual report and is not a problem unless it carries into the morning — in which case the dose moves earlier, not lower. Vivid dreams are commonly reported in the first fortnight and tend to settle. Morning grogginess that persists past week 2 is a message to your coach.

Week by week — what people typically notice and when

The protocol is only as good as the bedtime. Same lights-out every night including weekends, no screens in the last half-hour, the room cool and dark, and no alcohol — it fragments exactly the deep sleep the compound is being run for. Caffeine stops by early afternoon. The sleep log stays simple: time to sleep, number of wakings, how the morning felt, one to five.

Labs we ask for before and during

Ferritin and thyroid are the two labs that most often send a sleep problem somewhere other than a peptide, and they are corrected first. The morning cortisol repeat is optional and only worth doing if the baseline was drawn at the same time, after the same kind of night; otherwise the week-8 number cannot be compared. Magnesium in the evening, vitamin D and omega-3 are the only general supplements.

Stacking: what it pairs with

DSIP is the sleep corner of the library and is the compound most often added to something else. Alongside the nightly CJC-1295 + Ipamorelin pairing it covers both the GH pulse and the sleep architecture that pulse depends on — the two are injected separately, DSIP first, and the pairing belongs in a personalised protocol. Alongside a Semax morning or a Selank afternoon, it closes the day the other two opened.

For the researcher coming off a travel-heavy stretch, the short epithalon course is the reset and DSIP is what keeps the nights steady once it is over. DSIP sits quietly alongside the repair and skin pens and alongside a fat-loss cycle, where the sleep it supports is usually the thing those protocols are missing.

Common mistakes

• Dosing at bedtime instead of before it. 30–60 minutes before lights out. At the pillow is too late.
• A moving bedtime. The protocol is built on a fixed lights-out; a weekend that drifts two hours undoes the week.
• Judging it on a bad night. The read is the eight-week log against the two-week baseline. Nothing else.
• Going to 300 mcg on your own. The ceiling is a coach decision from week 5 if the log is flat, not a step.
• Drinking. Alcohol fragments deep sleep; the log cannot separate it from the compound.
• Skipping the baseline log. Two weeks of nights before the first dose, or there is nothing to compare the cycle against.